>> The recommendations cited here are a guide and may not be appropriate for use in all situations. Hand-searches of Published Literature (Primary Sources) Hand-searches of Published Literature (Secondary Sources) Searches of Electronic Databases. The evidence for outcomes from the included RCTs and, where appropriate, observational studies, were evaluated and presented using an adaptation of the 'GRADE toolbox' developed by the international GRADE working group (http://www.gradeworkinggroup.org/). When Prophylactic Platelet Transfusions Are Not Indicated. The following general principles were adhered to in developing the cost-effectiveness analysis: Full methods for the cost-effectiveness analysis for tranexamic acid and cell salvage are described in Appendix M of the full version of the guideline. The consensus recommendations were agreed through discussions in the GDG. The questions, the study types applied, the databases searched and the years covered can be found in Appendix G in the full guideline appendices. Assessments of potential differences in effect between subgroups were based on the chi-squared tests for heterogeneity statistics between subgroups. 24). Full guideline. ��C�F�]����]���CRJ�Xt���2M���7�1�o�͛����+o����%�=�\�R�r)�h�z:������za`s�N6��BXz`�~5�|�N���%�vH�[ o�Si/5HD�[��r J��9�I�őȑ�$J^H@\-&����v�ng_Y�bIg{� s^�kB� mYJ�e)������������v�a+�f�-3S��k�l��ӡٵ�f� Guideline recommendations should be based on the expected costs of the different options in relation to their expected health benefits (that is, their 'cost-effectiveness') rather than the total implementation cost. The GDG was involved in the design of the model, selection of inputs and interpretation of the results. Refer to Appendix F in the full guideline appendices for a flow diagram of economic article selection for the guideline. The evidence statements are presented by outcome and encompass the following key features of the evidence: The NICE economic evidence profile has been used to summarise cost and cost-effectiveness estimates. Published: 09/10/2020. When complications do occur, they're typically mild. A hierarchical Bayesian NMA was performed using the software WinBUGS version 1.4. For example, all RCTs started as High and the overall quality became Moderate, Low or Very low if 1, 2 or 3 points were deducted respectively. Also available for download in ePub and eBook formats from the NICE Web site. Conference abstracts were not automatically excluded from the review but were initially assessed against the inclusion criteria and then further processed only if no other full publication was available for that review question. Patients with Thrombocytopenia Who Are Bleeding. 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